Everything you need to know about NSAIDs

Nonsteroidal anti-inflammatory drugs are medications that relieve or reduce pain. The most popular examples of this group of drugs are aspirin and ibuprofen.

Nonsteroidal anti-inflammatory drugs (NSAIDs) also come under the wider definition of non-opioid analgesics. This means they are a separate type of painkiller from opioid drugs (such as morphine) that are typically used for more severe types of pain.

NSAIDs are usually taken for less severe types of pain that result from various problems involving aches and pains.

They include some of the most common pain relief drugs in the world, used by around 30 million Americans every day.

Fast facts on NSAIDs

The following are selected summary points about NSAIDs – further detail is on offer in the article.

  • Many NSAIDs are available over the counter (OTC) – they are generally safe as long as they are used according to the label.
  • NSAIDs may be preferable for cramps, aches and pains, or pain problems involving feveror swelling.
  • There are risks in regularly taking NSAIDs over a long period, so patients should seek medical advice for long-term pain complaints.

What are NSAIDs?

Inflammation is the immune system’s response to infection and injury. Heat, redness, swelling, and pain are noticeable signs of inflammation.

The body receives pain signals from nerve receptors when inflammation occurs. These signals result from complex responses and interactions between cells and chemicals in the body.

Anti-inflammatory drugs reduce pain partly by reducing inflammation. People can use these drugs to relieve symptoms of pain, stiffness, swelling, and fever.

The painkilling action of NSAIDs reduces the direct effect of inflammation on pain-nerve stimulation and sensitivity, but also the indirect effect of inflammatory heat and swelling.

Examples of NSAIDs

OTC NSAIDs include:

  • Ibuprofen
  • Aspirin
  • Naproxen Sodium

Prescription NSAIDs include:

  • Oxaprozin
  • Etodolac
  • Indomethacin
  • Naproxen
  • Nabumetone
  • Diclofenac
  • Vimovo (Naproxen/Esomeprazole)

Function

NSAIDs are a broad group of drugs from a number of different classes. Although their chemical structures are different, they have the following effects in common:

  • they reduce high temperature and fever
  • they reduce inflammation
  • they reduce pain

NSAIDs work by slowing the formation of compounds known as prostaglandins. Prostaglandins play an important role in the body’s inflammatory response. Reducing the amount of prostaglandins that are produced by tissue damage reduces inflammation.

NSAIDs block an enzyme called cyclooxygenase, also known as COX. The COX enzyme helps the reactions that produce prostaglandins.

Blocking COX also interferes with platelets – cells in the blood involved in clotting. This is why NSAIDs have anti-clotting properties.

In the case of aspirin, this property helps prevent the blocked arteries that can cause heart attacksor stroke.

What are NSAIDs used to treat?

NSAIDs are used for three broad symptom types that occur in a range of conditions:

  • high temperature or fever
  • inflammation
  • pain

NSAIDs are used to ease pain in a number of conditions, including:

  • arthritis
  • backache – particularly long-term pain in the lower back
  • cold or flu
  • headaches
  • period pains
  • joint or bone injuries, sprains, and strains
  • muscle or joint complaints
  • toothache

In low doses, aspirin is used to help prevent artery disease that can lead to heart attack or stroke. It may also be used to reduce the risk of some types of colorectal cancer.

Headache and lower back pain are two of the more common reasons for using NSAIDs. If these problems become long-term issues, patients should consider the safety of using NSAIDs.

Using NSAIDs for cold and flu

For more than 100 years, NSAIDs have been taken to treat symptoms of the common cold.

However, these drugs do not kill the virus or improve the course of the illness. NSAIDs simply relieve some of the symptoms, including fever and pain.

A systematic review of the best available evidence for treating a common cold with NSAIDs shows that they produce significant results against headache, ear pain, and muscle and joint pain.

Precautions for using NSAIDs

How the body responds to NSAIDs varies from person-to-person, and some people will experience side effects.

High doses and long-term use make some side effects more likely.

Here are some general points regarding the precautions of NSAIDs:

  • Alcohol does not have an interaction with these particular painkillers, although drinking excessive amounts while using NSAIDs can irritate the gut and increase the risk of internal stomach bleeding.
  • People using other medications should let their pharmacist or doctor know.
  • Taking more than one kind of NSAID can also have adverse effects.
  • Patients should always follow the label for the particular NSAID they are using because every NSAID is different.
  • Individuals should not take NSAIDs at the same time as anti-clotting drugs, such as aspirin or warfarin.
  • Children under 16 years of age and people over 65 may need to avoid taking NSAIDS.

Other people who may need to avoid these drugs or take them with medical guidance:

  • people who are allergic to NSAIDs
  • asthma- this can be worsened by NSAIDs in some cases
  • women who are pregnant or breast-feeding
  • anyone with heart disease

Side effects of NSAIDs and long-term safety

 

Aside from the precautions mentioned above, taking NSAIDs can have side effects.

Serious side effects are less common than mild ones, and the likelihood of any side effect varies between people. People taking drugs in high doses or over a long term are more likely to have side effects.

Prescription NSAIDs generally have a greater risk and greater painkilling power when compared with OTC NSAIDs.

Less severe side effects experienced by some people include:

  • indigestionand other gut complaints
  • headaches
  • dizziness
  • drowsiness

Adverse events rarely associated with NSAIDs include problems with:

  • fluid retention
  • kidneys (see below)
  • liver
  • heart and circulation

Blood pressure – NSAIDs can increase blood pressure. They reduce blood flow to the kidneys, meaning that they work less hard. In turn, this causes a fluid build up in the body. If there is more fluid in the bloodstream, blood pressure rises. In the long term, this can cause kidney damage.

Also, the risk of heart attack and stroke is slightly increased by taking NSAIDs, although not when taking low-dose aspirin.

Peptic ulcers and gastrointestinal bleeding

Long-term or high-dose use of NSAIDs could also lead to ulcers developing in the gut, known as peptic ulcers. NSAIDs reduce the actions of prostaglandins, which reduces inflammation; however, prostaglandins also protect the stomach lining by helping it to produce mucus. In this way, NSAIDs leave the stomach open to the effects of acid.

People who take NSAIDs for a long time or at high doses should consult their doctor about ulcer prevention. One option is to take separate drugs that reduce acid production in the stomach. Using a different type of painkiller is another option.

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